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Oral Diseases and Disorders Research - (Dental and Craniofacial Research) - #93.121

To improve oral, dental and craniofacial health through research, research training, and the dissemination of health information. The research portfolio supports basic, clinical and transitional research from molecular biology to patient-oriented and community-based clinical investigations. The Developmental Biology and Genetics Program supports research on etiology, pathogenesis, epidemiology, prevention, diagnosis, and treatment of inherited craniofacial-oral-dental diseases and disorders (e.g., ectodermal dysplasia, cleft lip and palate, amelogenesis imperfecta, dentionogenesis imperfecta, osteogenesis imperfecta, and other inherited diseases that have craniofacial-oral-dental manifestations) as well as on normal craniofacial-oral-dental development, and genome-wide association studies. 2. The Translational Genetics and Genomics program supports genetic/genomic research using epidemiologic and family-based methods, gene discovery using high throughput technologies, and gene-enivronment interactions. 3. The Microbiology Program supports basic and translational research on the role of oral microbes in health and disease including the etiology, pathogenesis, diagnosis, treatment, and prevention of oral infectious diseases. Areas of interest include biofilms and microbial ecology, microbial genomics and metagenomics, microbial virulence and disease pathogenesis, prevention and treatment. 4. The AIDS and Immunosuppression Program supports basic, translational and clinical research on HIV infection and AIDS to advance understanding of the underlying molecular, cellular, and genetic mechanisms that enable or prevent HIV infection and development of oral complications associated with AIDS and AIDS malignancies. 5. The Immunology and Immunotherapy Program supports basic and translational research on the immune aspects of oral diseases such as caries and periodontal diseases. The program includes host responses to microbes, immunology of biofilms, oral inflammation, systemic diseases, immunotherapy, immunopathologies, and host susceptibility to infection. 6. The Epithelial Cell Regulation and Transformation Program supports supports basic and translational research on the molecular mechanisms of oral epithelial cell regulation as they relate to the development and progression of diseases of the oral mucosa, including head and neck cancer. The program also supports and encourages the application of genomic, proteomic, and imaging technologies through research on the early diagnosis, prevention, and treatment of head and neck cancers. 7. The Mineralized Tissue and Salivary Gland Physiology Program supports basic and translational research on craniofacial skeletal biology and pathobiology including the physiology of tooth, bone and cartilage, and associated disorders and diseases, saliva and salivary glands, and pharmacogenetics. The goal of the program is to promote interdisciplinary and multidisciplinary approaches to advance the understanding of normal and abnormal processes underlying oral, dental and craniofacial diseases and disorders. 8. The Molecular and Cellular Neuroscience Program supports supports basic and translational research on orofacial pain and neuropathies, temporomandibular joint and muscle disorders, development of biomarkers for diagnostics and prognostics and development of therapeutics. 9. The Tissue Engineering and Dental and Craniofacial Rengenerative Medicine Program supports basic and translational research on the reconstruction, remodeling and repair of the oral and craniofacial tissues damaged as a result of disease or injury. The goal of this scientific program is to promote interdisciplinary and multidisciplinary approaches to engineering of biocompatible oral and craniofacial tissue constructs and their functional integration into the host tissue microenvironment. The program also supports efforts that employ bioengineering approaches for restoration, remodeling and regeneration of diseased and injured native host tissues. 10. The Dental and Biomaterials Program supports basic and translational extramural research on dental materials and devices, dental implants, biocompatibility of dental restorative materials, and biomaterials for craniofacial reconstruction. 11. The Behavioral and Social Sciences Research Program supports basic and applied BSS research to promote oral health, to prevent oral diseases and related disabilities, and to improve management of craniofacial conditions, disorders and injury. 11. The Center for Clinical Research supports clinical trials, dental practice based research networks, epidemiology research, and health disparities research. The Research Training and Career Development Program insures the future of dental and craniofacial research by developing an outstanding and diverse scientific work force through training and fellowship programs designed primarily for graduate, and post-doctoral stages of education, including dual degree (DDS, PhD) programs, as well as for continued career development of scientists and retraining of mid-career scientists. Diversity fellowships serve to expand the diversity of the scientific work force by supporting the training of predoctoral students from underrepresented groups. The Small Business Innovation Research (SBIR) program seeks to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The Small Business Technology Transfer (STTR)STTR program seeks to stimulate and foster scientific and technological innovation and foster technology transfer through cooperative research and development carried out between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.




(Salaries) FY 09 $287,349,000; FY 10 $296,110,000; FY 11 $298,905,000

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