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Child Health and Human Development Extramural Research - (NICHD Eunice Kennedy Shriver National Institute of Child Health and Human Development) - #93.865

Fiscal Year 2010: No Current Data Available Fiscal Year 2011: Fiscal year 2011 competing and noncompeting research project grants estimates are 1,764. Of this number, 83 are expected to be SBIR/STTR awards. Approximately 55 research centers will be awarded. 476 other research grants are anticipated to be awarded. Projected institutional training awards are 747 in fiscal year 2011. The individual training award are projected for fiscal year 2011 to be 82. Fiscal Year 2012: No Current Data Available

Fiscal Year 2010: No Current Data Available Fiscal Year 2011: The NICHD will invest wisely in the strongest science, ensuring that our priorities fill critical knowledge gaps and exploit emerging opportunities, while addressing urgent public health needs. A planned NICHD initiative, utilizing the newest high-throughput genomic technologies, will leverage the research resources developed by the NIH Roadmap to support additional studies in developmental epigenetics. Epigenetic actions on gene expression may critically influence early development from before birth and at key stages throughout childhood, serving as a mediator between genetics and the environment. Thus epigenetic research will lead to a better understanding of birth defects, developmental disabilities, obesity, and other conditions. To translate scientific knowledge into new and better treatments, the NICHD will continue to examine how medication during pregnancy and delivery affects the mother and the fetus. Researchers will examine why children respond differently than adults to certain drug therapies, and apply this knowledge to improve safety, efficacy, and dosage in children. Such studies will include cutting-edge research in pharmacogenomics, linking different pharmacological outcomes to genetic differences in individuals and laying the foundation for future research in personalized medicine. NICHD will take strategic advantage of existing resources and infrastructure to ensure that scientific research improves health care. Scientists will assess the newest treatment approaches, but researchers will also evaluate the safety and efficacy of more established treatments for which safety and efficacy data are currently inadequate. The NICHD will invest in the development of new medical devices specifically for fragile infants in neonatal intensive care units, rather than relying on miniaturized versions of instruments designed for adults. NICHD researchers will work to identify the earliest developmental paths leading to obesity. We will address the understudied area of maternal obesity and its immediate and long-term impact on women and their children. Rehabilitation research priorities include better understanding of the immediate and long-term outcomes of critical care treatment of children and of autonomic dysreflexia, a grave and little-studied complication of spinal cord injury that often occurs unexpectedly. The NICHD will continue efforts to promote women’s and children’s health around the globe, including studies to improve birth outcomes, to reduce maternal-fetal transmission of HIV, and to address interactions between iron deficiency and malaria. Reinvigorating the U.S. biomedical research community will be essential in the next decade. NICHD will build on successful training and career development programs to recruit and mentor the next generation of scientists. The Institute’s focus on developmental processes, in both the child and the adult, will continue to provide the basic scientific and clinical insights needed to improve care for a wide range of conditions affecting many populations. Fiscal Year 2012: No Current Data Available

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